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Congresso Brasileiro de Microbiologia 2023
 		Resumo: 1277-1

1277-1

ANTIBACTERIAL POTENTIAL OF AROMATIC COMPOUNDS DERIVED FROM PLANT AGAINST PLANKTONIC FORMS OF Staphylococcus sp. ISOLATES FROM CANINE EAR INFECTIONS.

Autores:
Romério Alves Silva (UECE - UNIVERSIDADE ESTADUAL DO CEARÁ ) ; Benise Ferreira da Silva (UNINTA - 2CENTRO UNIVERSITÁRIO INTA, UECE - UNIVERSIDADE ESTADUAL DO CEARÁ ) ; Andrey Carvalho Chaves (UECE - UNIVERSIDADE ESTADUAL DO CEARÁ ) ; Lucivanny Araújo Moreira (UNINTA - 2CENTRO UNIVERSITÁRIO INTA) ; Rayanderson Maciel Vasconcelos (UNINTA - 2CENTRO UNIVERSITÁRIO INTA) ; Felipe José Negreiros de Carvalho (UNINTA - 2CENTRO UNIVERSITÁRIO INTA) ; Isaac Nego Goes da Silva (UECE - UNIVERSIDADE ESTADUAL DO CEARÁ ) ; Victor Alves Carneiro (UNINTA - 2CENTRO UNIVERSITÁRIO INTA)

Resumo:
Ear infections have become a major problem in the clinical routine of companion animals. Among the main microorganisms involved in this type of infection, those belonging to the genus Staphylococcus stand out. However, it is important to highlight that the inappropriate use of drugs can compromise the treatment, which can lead to the development of bacterial resistance, which is a growing concern in veterinary medicine. To deal with this challenge, it is necessary to look for new alternatives that can be used in combination with existing drugs or even alone, aiming at an effective treatment with less probability of microorganisms developing resistance. In this sense, the use of plant compounds that have antimicrobial potential against multidrug-resistant bacteria has been reported in the literature. Thus, the aim of this study was to evaluate the antibacterial activity of eugenol, trans-cinnamaldehyde and geraniol against six strains of different Staphylococcus species previously isolated from canine ear infections. The antibacterial activity of the compounds was evaluated using the agar disk diffusion method and broth microdilution assay to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results obtained demonstrate that all strains tested were sensitive to plant compounds. Emphasis on trans-cinnamaldehyde, which showed an inhibition zone between 27 and 35 mm, with a MIC of 250 to 500 µg/mL. For eugenol, the strains showed inhibition halos varying between 13 and 17 mm, with MIC between 2,000 and 4,000 µg/mL. Finally, the tested strains showed halos between 10 and 14, and MIC of 500 µg/mL when tested against geraniol. Additionally, MBC values were equal to MIC for all tested strains and compounds. Thus, the present study encourages further research with prospects for the application of these compounds as antibacterials in the development of new therapeutic alternatives in the fight against ear infections caused by the genus Staphylococcus sp. in dogs.

Palavras-chave:
 Terpenes, Antibacterial activity, Canine otitis


Agęncia de fomento:
Cearense Foundation for Scientific and Technological Development (FUNCAP) and National Council for Scientific and Technological Development (CNPq).